In lead optimisation exploration of chemical space around your scaffold is limited by the availability of suitable reagents which work with your chemistry. Thus sets of chemically related reagents which allow introduction of novel R groups can improve the chance of identifying the optimum compound.
Recent industry trends favour the inclusion of cyclic chiral reagents during SAR exploration since they:
However chiral reagents are traditionally expensive, are of limited availability (even with pairs of enantiomers) and are difficult to scale-up.
EnzaCore™ SAR Explorer Panels are a new set of products enabling the rapid incorporation of a variety of chiral cyclic building blocks provided in ready to use format. Each set has been designed by state of the art computational chemistry to provide:
The panels thus provide convenient exploration of SAR with groups of novel reagents as a cost effective solution.
EnzaCores™ are produced by biocatalytic processes providing exquisite enantiomeric excesses in production. This route of manufacture ensures rapid scale-up possibilities.
There are currently 4 EnzaCore™ SAR Explorer Panels produced using this technology now available, each featuring:
Contact us today to receive further information on these products:
Email Prosarix Sales or phone +44 1223 870400